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Filtered Search Results
Medchemexpress LLC PROTAC BET Degrader-10 | 1957234-97-7 | 99.4% | 783.29 | 50 MG
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PROTAC BET Degrader-10 (dBET37) is a potent BET protein BRD4 degrader. It is connected by ligands for Cereblon and BRD4, and has a DC50 of 49 nM. This product is for research use only and not sold to patients. PROTACs use two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase and the other targets the protein of interest. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Potent BET protein BRD4 degrader
- Utilizes the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- Connected by ligands for Cereblon and BRD4
- DC50 of 49 nM
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eMolecules 778270-11-4 | Medchem Express | GNF-2 | 5mg | 446259752 | HY-11007 | MFCD09265253 | 374.323 | C18H13F3N4O2
Medchem Express | GNF-2 | 5mg | 446259752 | HY-11007 | 778270-11-4 | MFCD09265253 | 374.323 | C18H13F3N4O2
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Medchemexpress LLC Salicyluric acid | 487-54-7 | 99.8% | 195.17 | 250 MG
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Salicyluric acid is an endogenous metabolite, exclusively for research purposes and not intended for patient use. This product is provided as a solid, white to off-white in appearance, with a molecular weight of 195.17. It is classified under phenols, monophenols, ketones, aldehydes, and acids, targeting both microbial and human endogenous metabolites.
- Molecular weight: 195.17
- Formula: C9H9NO4
- CAS no.: 487-54-7
- Appearance: Solid
- Color: White to off-white
- Structure classification: Phenols, monophenols, ketones, aldehydes, acids
- Initial source: Endogenous metabolite
- Target: Endogenous metabolite
- Pathway: Metabolic enzyme/protease
- Shipping: Room temperature in continental US; may vary elsewhere
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000702614 KG-548 250MG
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Apexbio Technology LLC Tozadenant 870070-55-6 250mg
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Tozadenant is a small-molecule antagonist targeting the adenosine A2A receptor It is designed to selectively inhibit A2A receptors thereby modulating the indirect basal ganglia pathway and influencing neuronal activity involved in motor control Tozadenant exerts its biological activity primarily through selective A2A receptor blockade In animal models tozadenant demonstrates enhancement of motor neuron function Human studies using perfusion MRI indicate that administration of tozadenant decreases regional cerebral blood flow particularly in bilateral thalamic areas Based on these pharmacological properties tozadenant holds research potential in investigating Parkinson s disease and movement disorders associated with basal ganglia dysfunction
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Medchemexpress LLC 3-Azidopropanol | 72320-38-8 | C3H7N3O | 250 MG
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3-Azidopropanol is an azide-containing alcohol and a click reaction substrate. It undergoes a copper-catalyzed addition reaction with propargyl alcohol.
- Azide-containing alcohol
- Click reaction substrate
- High purity (99.52%)
- Stable under recommended storage conditions
- Colorless to light yellow liquid appearance
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Ambeed AMBEED
5000870202 3-1-PYRAZOLYLANILINE 250MG
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Medchemexpress LLC Copanlisib dihydrochloride | 1402152-13-9 | C23H30Cl2N8O4 | 50 MG
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Copanlisib dihydrochloride is a potent, selective, and ATP-competitive pan-class I PI3K inhibitor. It exhibits IC50 values of 0.5 nM for PI3Kα, 0.7 nM for PI3Kδ, 3.7 nM for PI3Kβ, and 6.4 nM for PI3Kγ. This compound demonstrates superior antitumor activity and shows over 2,000-fold selectivity against other lipid and protein kinases, with the exception of mTOR.
- Induces apoptosis in a subset of tumor cell lines resistant to certain treatments.
- Shows complete inhibition of PI3K-mediated AKT phosphorylation in ELT3 cells at 5 nM.
- Potently inhibits cell proliferation in various human tumor cell lines, particularly those with PIK3CA-activating mutations or HER2-positive.
- Significantly increases caspase-9 activities and levels of phosphorylated p53 at Ser15 and cleaved PARP in BT20 breast cancer cells.
- Demonstrates robust antitumor activity in rat KPL4 tumor xenograft models, with high tumor growth inhibition rates.
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Ambeed AMBEED
5000870847 METHYL 3-CYCLOPENTYLAMIN 250MG
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Chem-Impex International, Inc. 4-Chloro-6,7-dimethoxyquinazoline | 13790-39-1 | MFCD01570172 | 5G
4-Chloro-6,7-dimethoxyquinazoline, 13790-39-1, MFCD01570172, 5G
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Medchemexpress LLC AC 187 | 151804-77-2 | 98.9% | 2890.21 | 10 MG
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AC 187 is a potent and orally active amylin receptor antagonist. It demonstrates high selectivity for the amylin receptor compared to calcitonin and CGRP receptors. This compound exhibits neuroprotective effects by blocking amyloidβ protein (Aβ)-induced neurotoxicity and improving neuronal survival.
- Potent and orally active amylin receptor antagonist
- High selectivity for the amylin receptor
- Exhibits neuroprotective effects
- Blocks amyloidβ protein (Aβ)-induced neurotoxicity
- Improves neuronal survival
- Attenuates activation of caspases mediating Aβ-induced apoptotic cell death
- Increases glucagon concentration
- Accelerates gastric emptying of liquids
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Medchemexpress LLC HY-10115 100mg Medchemexpress, PI-103 CAS:371935-74-9 Purity:98%
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Medchemexpress,HY-10115 100mg PI-103 CAS:371935-74-9 Formula:C19H16N4O3 PI-103 is a potent PI3K and mTOR inhibitor with IC50s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and mTORC2. PI-103 also inhibits DNA-PK with an IC50 of 2 nM. Purity:98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Eprinomectin | 123997-26-2 | 98.02% | 914.13 | 250 MG
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Eprinomectin (MK-397) is an avermectin type that acts as a broad-spectrum fungicide with insecticidal, insecticidal, and acaricidal properties. It also induces apoptosis and autophagy in prostate cancer cells, demonstrating antitumor activity.
- Broad-spectrum fungicide
- Insecticidal, insecticidal and acaricidal activities
- Induces apoptosis and autophagy in prostate cancer cells
- Antitumor activity
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000703122 1-IODOADAMANTANE 250MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000704060 2-PYRIDYL-2-YLIMID 1G
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